Glucosamine is a well-liked dietary complement used to deal with osteoarthritis.
Osteoarthritis is a degenerative illness attributable to inadequate regeneration of cartilage in joints, most frequently within the knees and hips.
It will get worse over time and causes joint ache, difficulties strolling and incapacity.
There isn’t a recognized treatment, however there are a couple of methods to doubtlessly sluggish the method. Many individuals attempt to stave off osteoarthritis by taking glucosamine dietary supplements.
However do they actually work? This text takes a have a look at the proof.
What Is Glucosamine?
Glucosamine is a pure amino sugar produced by your physique. It is usually a dietary complement marketed in its place therapy for osteoarthritis.
The very best pure focus of glucosamine is in joints and cartilage the place it makes up the construction of glycosaminoglycans, compounds important for joint well being (1).
Dietary supplements are usually processed from crustacean shells or produced by the bacterial fermentation of grains (2).
They’re extensively accessible and bought within the type of tablets, capsules, smooth gels or drink mixes. There are two most important varieties: glucosamine sulfate and glucosamine hydrochloride.
The way in which glucosamine impacts arthritis is unclear. Scientists consider naturally occurring glucosamine helps shield the cartilage inside your joints (Three).
Moreover, a number of research counsel that taking glucosamine dietary supplements might cut back collagen breakdown (four, 5).
The dietary supplements might also work by decreasing irritation, which is without doubt one of the most important causes of joint cartilage breakdown in osteoarthritis sufferers (6).
Nevertheless, the effectiveness of those dietary supplements is debated.
Abstract: Glucosamine is a dietary complement usually used to deal with osteoarthritis. Scientists are usually not totally certain the way it works, however research counsel it might cut back cartilage breakdown.
Do These Dietary supplements Work for Arthritis?
Glucosamine is without doubt one of the world’s hottest dietary supplements. It’s additionally among the many most controversial.
Right here is the analysis about the way it impacts the 2 frequent kinds of arthritis.
Whereas many research conclude that glucosamine has no advantages for osteoarthritis, others point out that it might relieve joint ache and different signs over time.
This particularly applies to glucosamine sulfate salts, a formulation patented by the pharmaceutical firm Rottapharm.
One managed research in 318 adults with osteoarthritis discovered that taking 1,500 mg of the “Rotta formulation” day by day for half a yr decreased ache and improved perform greater than a placebo.
The advantages appeared much like a day by day Three-mg dose of acetaminophen — a generally used ache reliever (7).
One other two research, which included round 200 folks, confirmed that taking 1,500 mg of glucosamine sulfate day by day for 3 years improved their total signs — together with ache, stiffness and performance — in comparison with a placebo (eight, 9).
Nevertheless, these research have been presumably industry-influenced since Rottapharm financed all three. Presently, no massive, long-term, industry-independent research on the effectiveness of glucosamine can be found.
An unbiased evaluation of a number of high-quality research concluded that the “Rotta formulation” improved sure measures of ache and performance greater than a placebo, whereas different kinds didn’t present any vital advantages (10).
That stated, the advantages of taking glucosamine sulfate are small and a few researchers think about them clinically irrelevant (11).
Abstract: The advantages of this complement are controversial. Some research counsel that glucosamine sulfate might barely enhance osteoarthritis signs when taken for no less than half a yr.
Osteoarthritis shouldn’t be confused with rheumatoid arthritis, which is far much less frequent.
Rheumatoid arthritis is an autoimmune illness during which the immune system assaults the joints. In contrast to osteoarthritis, it’s not attributable to on a regular basis put on and tear.
Scientists have usually assumed that glucosamine has no advantages for rheumatoid arthritis.
Nonetheless, one research in 51 adults with rheumatoid arthritis suggests in any other case. It discovered that taking 1,500 mg of glucosamine hydrochloride for 3 months improved self-assessed signs greater than a placebo (12).
Nevertheless, extra research want to substantiate these findings earlier than any strong conclusions may be made.
Abstract: Restricted proof signifies that glucosamine hydrochloride might enhance signs in folks with rheumatoid arthritis. Nevertheless, extra research are wanted.
Find out how to Purchase Glucosamine
These dietary supplements are extensively accessible and straightforward to search out.
Glucosamine sulfate seems to be more practical than glucosamine hydrochloride, so for those who determine to attempt these dietary supplements, your greatest wager is the sulfate kind (13, 14).
One other issue to contemplate is the standard of the product you’re shopping for. One research discovered that the quantity of glucosamine in dietary supplements was usually decrease than reported (15).
Glucosamine high quality is carefully monitored in most European nations the place it’s marketed as a pharmaceutical. In North America, it’s categorized as a nutraceutical, and its manufacturing and advertising might not be as strictly managed.
In case you are shopping for American dietary supplements, select people who have a top quality certification from a third-party company. These embody Knowledgeable Selection, NSF Worldwide and the US Pharmacopeial Conference (USP).
Moreover, glucosamine is commonly bought together with chondroitin sulfate, a complement additionally used to scale back the signs of osteoarthritis.
Its effectiveness is debated, however some research counsel it might cut back ache when used alone or together with glucosamine (16).
Abstract: In the event you determine to complement with glucosamine, select merchandise that comprise the sulfate kind and have a top quality certification.
Dosage and Aspect Results
Typically, glucosamine must be taken with meals 3 times per day.
Doses often vary from 300–500 mg with every meal, including as much as a complete day by day dose of 900–1,500 mg. Most research used 1,500 mg per day.
Salts of glucosamine sulfate or the “Rotta formulation” solely must be taken as soon as per day. Be certain that to observe the directions on the packaging.
These dietary supplements are thought of secure and no critical uncomfortable side effects have been reported. Flatulence is the most typical grievance.
Research additionally point out that glucosamine injections might worsen insulin sensitivity, however dietary supplements don’t appear to have the identical impact (17).
Abstract: Glucosamine dietary supplements are thought of secure and don’t have any critical uncomfortable side effects. The usual dosage is 1,500 mg per day.
The Backside Line
Glucosamine is a controversial complement.
Many research haven’t detected any vital advantages, whereas others counsel the sulfate kind might cut back the signs of osteoarthritis and delay or sluggish its improvement.
Nonetheless, some scientists nonetheless doubt the effectiveness of glucosamine or think about its small advantages clinically irrelevant.
Whereas glucosamine isn’t any magic resolution, others level out that dietary supplements can not damage and could also be higher than no therapy in any respect.